628 results
NSAIDS and their effects on the Kidney - Pathophysiology

Arachidonic Acid metabolites into alternative pathways that modify
NSAIDS and their effects ... Pre renal AKI Idiosyncratic ... KidneyDisease #nephrology #Effects
Neuroleptic Malignant Syndrome - Diagnosis
Neuroleptic Malignant Syndrome is an idiosyncratic reaction to antipsychotic medications classically characterized
Syndrome is an idiosyncratic ... tremor → cogwheel effect
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Management of Idiosyncratic ... acetaminophen/APAP) • Idiosyncratic ... less common, only affects ... Liver #Injury #Idiosyncratic
Chloramphenicol - Antibiotics Class Overview

– 50S ribosomal inhibitor.   IV or PO (but PO form
, dose-related effect ... anemia – rare, idiosyncratic
Drug-Induced Liver Injury - Pathophysiology
Indirect
Idiosyncratic
Direct

BWH Medicine Chiefs @BrighamChiefs

#DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Pathophysiology Indirect Idiosyncratic
Antipsychotic Side Effect Profiles (Typical / AtypicaI)

Listed by Extrapyramidal Side Effects (EPSE), Weight Gain, Elevated Prolactin
Antipsychotic Side Effect ... Extrapyramidal Side Effects
Effect of Anticoagulants on Coagulation Tests
PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Effect of Anticoagulants ... Diagnosis #Laboratory #Effects
Adverse Effects of NSAIDs
Prostaglandins decreased
 - Gastric mucosal damage with ulcer formation, bleeding, and perforation
 -
Adverse Effects ... proinflammatory effect
Vasculitis - Break down based on vessel size 
Distribution of vessel involvement by large vessel vasculitis,
vasculitis can affect ... vessel vasculitis affects ... predominantly affects ... predominantly affects ... vasculitis rarely affects
Opioid Use Disorder Medications - Pharmacokinetics

Buprenorphine is a partial mu-opioid receptor agonist with low intrinsic activity,
leading to prolonged effects ... produces a ceiling effect ... pharmacological effects ... by blocking the effects ... to block their effects