2006 results
Cryoglobulinemia Classification Types

Type 1: Monoclonal IgM (rarely IgG/lgA)
 • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
1: Monoclonal IgM ... (rarely IgG/lgA ... 2: Monoclonal IgM ... and polyclonal IgG ... Types #hematology #diagnosis
Diagnosis of IgA Vasculitis (Henoch-Schönlein Purpura) - French Vasculitis Study Group 

1) Suggestive clinical manifestations
Diagnosis of IgA ... 1) Suggestive clinical ... individuals - Clinical ... Elevated serum IgA ... HenochSchonleinPurpura #HSP #Diagnosis
Commonly Used Diagnostic Tests for Celiac Disease

Tissue transglutaminase (tTG) IgA antibodies
 - Most reliable noninvasive test
Commonly Used Diagnostic ... patients with IgA ... and specificity IgA ... disease less than IgA ... Laboratory #Tests #Diagnosis
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
IgA Vasculitis – ... Pathogenesis and Clinical ... (GD-IgA1). ... -> Decr IgA serum ... Pathophysiology #Diagnosis
Celiac Disease Testing Algorithm
INDICATIONS FOR TESTING:  Nonspecific symptoms (iron-deficiency anemia, failure to thrive, fever, skin
Immunoglobulin A • tTG IgA ... • tTG IgG and ... IgG by IFA • DGP ... IgA • HLA testing ... Testing #Algorithm #diagnosis
You’ll notice there is an IgM and an IgG core antibody. The presence of IgM anti-HBc
and an IgG core ... The presence of IgM ... IgM anti-HBc is ... commonly run in the clinical ... #Diagnosis #HepB
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm
INDICATIONS FOR TESTING:
 • Vascular thrombosis
- 1 or more clinical ... and IgM • Beta ... Cardiolipin Antibody, IgA ... Glycoprotein 1 Antibody, IgA ... Workup #Algorithm #diagnosis
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
AIHA: - 70%; IgG ... mediated - DAT: IgG ... AIHA: - 20%; IgM ... mediated - DAT: IgG ... Pathophysiology #diagnosis
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
IgM monoclonal ... immunoglobulin is an IgA ... or IgG isotype ... (rarely IgD or IgE ... Significance #hematology #diagnosis
Comprehensive pathogenesis of IgA Nephropathy (i.e Berger’s Disease). 

IgA Nephropathy is the most common cause of
pathogenesis of IgA ... IgA Nephropathy ... complement to IgA ... medexplosion.com/iga-nephropathy-short-note-flash-cards ... BergersDisease #clinical