2987 results
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... non-essential drug/HDS treatments ... Autoantibody titres, ↑ IgG ... Injury #Diagnosis #Algorithm
Subtypes of Serum Proteins

Pre-albumin (Transthyretin)
Albumin
Globulins
 • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Transferrin • Gamma: IgM ... , IgG, IgA, RF, ... Proteins #Subtypes #algorithm
Warm vs Cold Autoimmune Hemolytic Anemia
Warm Autoimmune Hemolytic Anemia:
 • Mechanism: IgG and Complement-mediated
 • Etiology:
• Mechanism: IgG ... Coombs positive for IgG ... Spherocytes • Treatment ... • Mechanism: IgM ... transient hemolysis • Treatment
Cryoglobulinemia Classification Types

Type 1: Monoclonal IgM (rarely IgG/lgA)
 • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
1: Monoclonal IgM ... (rarely IgG/lgA ... and polyclonal IgG ... and polyclonal IgG ... and polyclonal IgG
You’ll notice there is an IgM and an IgG core antibody. The presence of IgM anti-HBc
and an IgG core ... IgM anti-HBc is ... The presence of IgG ... infected with HBV, IgG ... and IgG anti-HBc
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
AIHA: - 70%; IgG ... mediated - DAT: IgG ... AIHA: - 20%; IgM ... mediated - DAT: IgG
Management of adult IgA Vasculitis (Henoch-Schönlein purpura) - Treatment algorithm for the management of IgAV patients
Henoch-Schönlein purpura) - Treatment ... algorithm for the ... Treatment remains ... HSP #Management #Treatment ... Rheumatology #Vasculitis #Algorithm
Commonly Used Diagnostic Tests for Celiac Disease

Tissue transglutaminase (tTG) IgA antibodies
 - Most reliable noninvasive test
negative with IgA ... transglutaminase (tTG) IgG ... patients with IgA ... antibody test IgG ... Reflects response to treatment
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
allergies Type II - IgG ... antigen - IgG ... or IgM antibody ... IgG can also mediate ... Type Ill - IgG and
Celiac Disease Testing Algorithm
INDICATIONS FOR TESTING:  Nonspecific symptoms (iron-deficiency anemia, failure to thrive, fever, skin
Disease Testing Algorithm ... • tTG IgG and ... DGP IgGa • EMA ... IgG by IFA • DGP ... Disease #Testing #Algorithm