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diagnosis differential management causes treatment cardiology nephrology gastroenterology hematology peds workup ddxof pulmonary em pediatrics evaluation neurology criticalcare endocrinology dermatology
Subtypes of Serum Proteins Pre-albumin (Transthyretin) Albumin Globulins • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Transferrin • Gamma: IgM ... , IgG, IgA, RF, ... Proteins #Subtypes #algorithm ... #classification
Cryoglobulinemia Classification Types Type 1: Monoclonal IgM (rarely IgG/lgA) • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
Cryoglobulinemia Classification ... (rarely IgG/lgA ... and polyclonal IgG ... and polyclonal IgG ... Cryoglobulinemia #Classification
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
allergies Type II - IgG ... antigen - IgG ... IgG can also mediate ... Type Ill - IgG and ... Hypersensitivity #Types #Classification
Types of hypersensitivity reactions Type I - lgE-Mediated, Within I Hour (Anaphylaxis) Type II - IgG or IgM
Anaphylaxis) Type II - IgG ... or IgM Cytotoxic ... reactions #Types #Classification
You’ll notice there is an IgM and an IgG core antibody. The presence of IgM anti-HBc
and an IgG core ... IgM anti-HBc is ... The presence of IgG ... infected with HBV, IgG ... and IgG anti-HBc
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
AIHA: - 70%; IgG ... mediated - DAT: IgG ... AIHA: - 20%; IgM ... mediated - DAT: IgG
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Mediator: IgM ... + IgG • Immunological ... Immunological Mediator: IgG ... Reactions #Types #Classification
Celiac Disease Testing Algorithm INDICATIONS FOR TESTING: Nonspecific symptoms (iron-deficiency anemia, failure to thrive, fever, skin
Disease Testing Algorithm ... • tTG IgG and ... DGP IgGa • EMA ... IgG by IFA • DGP ... Disease #Testing #Algorithm
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
IGG-4 RELATED DISEASE ... infiltration of IgG4 ... lesions - IgG4 ... Biliary Tract: IgG4 ... complement • Classification
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
Suggested algorithm ... small (<1.5 gm/dL) IgM ... low-risk MGUS (IgG ... #MGUS #Biopsy #algorithm
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