83 results
Eosinophilic angiocentric fibrosis: IgG4-related disease of the upper aerodigestive tract. Distinctive concentric (onion-skin) perivascular fibrosis and
angiocentric fibrosis: IgG4 ... Usually >50 IgG4 ... plasma cells/HPF, IgG4 ... :IgG >40%
IgG4-associated conditions

Diagnosis of IgG4 disease is depending on BIOPSY. While IgG4 levels can be informative (and
IgG4-associated ... Diagnosis of IgG4 ... While IgG4 levels ... inflammation of IgG4 ... #IgG4 #conditions
Manifestations of IgG4-related disease by organ system.
 The most common primary disease features are indicated in
Manifestations of IgG4 ... #IgG4 #Manifestations
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
IgG4-Related Disease ... node), high serum IgG4 ... laboratory tests: • IgG4 ... with increased IgG4 ... Mettler_K1000 #IgG4
Celiac Disease Testing Algorithm
INDICATIONS FOR TESTING:  Nonspecific symptoms (iron-deficiency anemia, failure to thrive, fever, skin
tTG IgA • tTG IgG ... and DGP IgGa • ... EMA IgG by IFA
Expected DAT Results in Autoimmune Hemolysis
DAT Negative Hemolysis
 • DAT Poly ( - ), IgG (
DAT Poly ( - ), IgG ... DAT Poly ( + ), IgG ... DAT Poly ( + ), IgG ... Poly ( +/- ), IgG ... DAT Poly ( + ), IgG
Diseases that mimic hematologic manifestations of IgG4-RD (lymphadenopathy, eosinophilia and polyclonal hypergammaglobulinemia).

#IgG4 #Disease #Mimics #Diagnosis #Hematology
manifestations of IgG4 ... #IgG4 #Disease #
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Rheumatic Diseases: IgG4 ... Related Disease (IgG4
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
AIHA: - 70%; IgG ... mediated - DAT: IgG ... mediated - DAT: IgG
Cryoglobulinemia Classification Types

Type 1: Monoclonal IgM (rarely IgG/lgA)
 • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
Monoclonal IgM (rarely IgG ... and polyclonal IgG ... and polyclonal IgG ... and polyclonal IgG