429 results
Cryoglobulinemia Classification Types

Type 1: Monoclonal IgM (rarely IgG/lgA)
 • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
1: Monoclonal IgM ... may be seen when IgM ... 2: Monoclonal IgM ... 25%): Polyclonal IgM ... 3: Oligoclonal IgM
You’ll notice there is an IgM and an IgG core antibody. The presence of IgM anti-HBc
notice there is an IgM ... The presence of IgM ... IgM anti-HBc is ... core antibody and IgM ... ) simply means IgM
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm
INDICATIONS FOR TESTING:
 • Vascular thrombosis
and IgM • Beta ... and IgM • Phosphatidylserine ... and IgMa • Phosphatidylserine ... Antibodies, IgG ... and IgMa • Prothrombin
Rouleaux formation is common in IgM gammopathy and may be particularly striking

Genevieve Crane, MD, PhD@evemariecrane

#Rouleaux #formation
formation is common in IgM ... Rouleaux #formation #IgM
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
IgM MGUS: • Serum ... IgM monoclonal ... can progress to IgM ... myeloma Non-IgM ... protein level (non-IgM
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
AIHA: - 70%; IgG ... mediated - DAT: IgG ... AIHA: - 20%; IgM ... mediated - DAT: IgG
Subtypes of Serum Proteins

Pre-albumin (Transthyretin)
Albumin
Globulins
 • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Transferrin • Gamma: IgM ... , IgG, IgA, RF,
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
or IgM - Cell-bound ... antigen - IgG ... or IgM antibody ... Type Ill - IgG and ... IgM - Soluble antigen
Hepatitis Virus Screening Algorithm
 - Hepatitis A Virus Antibody, IgM
 - Hepatitis B Virus Core Antibody,
Virus Antibody, IgM ... Core Antibody, IgM
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Idiopathic monoclonal IgM ... Immunoglobulin M (IgM ... Infections: Polyclonal IgM ... Diagnosis Monoclonal IgM ... Disorders Such As: • IgM