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Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
mutations) • Immune ... Aplastic Anemia Clinical ... and petechiae Causes ... HCV - HIV • Immune ... Aplastic #Anemia #oncology
Eosinophils (Eos) and hypereosinophilia (HE) Caused by eosinophilopoietic cytokines Common causes: - Drug reaction - Helminth infection -
hypereosinophilia (HE) Caused ... cytokines Common causes ... disease Rare causes ... malignancy - Immune ... Differential #Diagnosis #Causes
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm • Reactive (Inflammatory / Infectious) •
Causes of Diffuse ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Causes of Acute ... antibodies • Immune-complex ... lupus) • Pauci-immune ... legionella) • Immune ... Diagnosis #Algorithm #Causes
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
Pathogenesis and clinical ... produced from normal immune ... a maladaptive immune ... self-antigens are the cause ... antigens are the cause
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Oncologic Emergencies ... HEMATOLOGIC ONCOLOGIC ... STRUCTURAL ONCOLOGIC ... Constipation • Nausea ... Hyponatremia • Nausea
Check point inhibitors and Side Effects - Immune-related adverse events (IRAEs) What are the side effects? -
Side Effects - Immune-related ... - Immune-related ... - Most immune-related ... AdverseEffects #Oncology
Melanoma Pathogenesis Environmental exposure (UV light) + genetic susceptibility (CDKN2A, CDK4, MC1R, BRAF, p16/ARF genes) → accumulation
invasion, evasion of immune ... Pathophysiology #Oncology
Hemolysis Classification - Intrinsic and Extrinsic Causes Commentary: Another way to think of immune hemolysis would be
and Extrinsic Causes ... way to think of immune ... autoimmune (most of the causes ... Differential #Diagnosis #Causes
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Acquired • Immune ... • Non-lmmune ... Diagnosis #Algorithm #Causes
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