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management diagnosis treatment algorithm neurology pharmacology rheumatology cyclosporine drugs gravis myasthenia nephrology acuteinterstitialnephritis acutetubulointerstitialnephritis adverseeffects allergicinterstitialnephritis calcineurininhibitor cardiology causes corticosteroids
Immune Reactions and Immunosuppressant Drugs Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2 Muromonab-CD3 - Monoclonal antibody Calcineurin
Reactions and Immunosuppressant ... Mycophenolate mofetil #Immunosuppressant
Cyclosporine - common immunosuppressant for transplant rejection prevention. Originally isolated from fungi in the 1970's. #Pharmacology
Cyclosporine - common immunosuppressant
Myocarditis Diagnosis • Endomyocardial biopsy (gold standard, rarely performed) • Clinical presentation • Cardiovascular MRI Clinical •
myocarditis) • Immunosuppressants
Management of Acute Tubulointerstitial Nephritis (aka Acute Interstitial Nephritis). Simplified management algorithm for investigation and treatment
corticosteroids and other immunosuppressants
Drugs associated with hypokalemia and hypomagnesemia Hypokalemia - Shift from extracellular fluid to intracellular fluid compartment -
inhibitors - Immunosuppressants
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care TRICC - NEJM 1999 -
Transfusions are immunosuppressants
Proposed algorithm for choice of therapy or disease monitoring in sarcoidosis. Anti-inflammatory therapy: • Prednisolone • Prednisolone
Prednisolone + immunosuppressant
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Infection under immunosuppressants
Myasthenia Gravis - Summary • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
• The immunosuppressant
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
childbirth, tapering of immunosuppressants
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