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differential hemolytic management workup causes algorithm chronic cll leukemia lymphocytic mds monoclonal myelodysplastic agglutinin aplastic atlas autoimmune bloodcell cell classification
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Warm vs Cold Autoimmune ... Lymphoproliferative disorder ... , Autoimmune disorder ... #hematology #diagnosis ... #comparison
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
lymphoproliferative disorder ... infection, autoimmune disorder ... • Symptoms of anemia ... anemia • Cold ... #hematology #diagnosis
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Unstable hemoglobin disorders ... Cell Agglutinate: Cold ... , Paroxysmal cold ... #differential #diagnosis ... #hematology #microscopy
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Syndrome (MD) - Diagnosis ... : 70 years old, ... cytopenias (usually anemia ... Management #treatment #hematology ... #oncology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Autoimmune (AIHA)"Cold ... (e.g. primary cold ... lymphoproliferative disorders ... #hematology #anemia
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... Diseases Nail Fold ... Iron deficiency anemia ... Systemic #Secondary #dermatology ... #Differential #Diagnosis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... practices that could ... changes), high MCV anemia ... #Differential #Diagnosis ... Causes #Workup #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... Agglutination - Cold ... Consider RBC membrane disorder ... Algorithm #workup #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Anticonvulsants - Gold ... #oncology #hematology ... #diagnosis #management
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
leukemia in adults • Disorder ... minimal tumor burden Diagnosis ... 5) Symptoms of anemia ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
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