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differential lfts obstetrics pregnancy acute comparison elevation hellp hematology management obgyn thrombocytopenia transaminitis ttphus alkaline alp chemistry drug druginduced failure
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Injury (DILI) ... #differential #Diagnosis ... gastroenterology #algorithm ... gastroenterology #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential Diagnosis ... Algorithm Vascular ... Causes of Acute ... #algorithm #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Algorithm DILI ... for alternative causes ... #Injury #Diagnosis ... #Algorithm #hepatology
Table of Causes of Acute Liver Injury #Diagnosis #Hepatology #Acute #Liver #Injury #Causes #Differential #Incidence #Table #Failure
Table of Causes ... of Acute Liver Injury ... #Diagnosis #Hepatology ... #Acute #Liver # ... Injury #Causes #
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
abnormality vs bone Bili ... Hepatocellular injury ... 2: Cholestatic injury ... Transaminitis #diagnosis ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
injury < 26 weeks ... Unconjugated Bili ... > 90% of Total Bili ... #chemistry #diagnosis ... #differential #Hepatology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
of Pregnancy (AFLP ... child * Severe cases ... TTPHUS #HELLP #AFLP ... #obstetrics #hematology ... #diagnosis #table
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... = nonspecific (nausea ... 10x ULN), ↑Tbili/Dbili ... iMedEducation #AFLP ... Pregnancy #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
- Differential Diagnosis ... Algorithm ALP ... Highest • Bone • Liver ... Intestine - Other causes ... #Algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Algorithm Severe ... • Pregnancy - AFLP ... Others #LFTs #Hepatology ... #Algorithm #Causes
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