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hematology differential causes management oncology clinical skin algorithm leukemia platelets product rash reactions thrombocytosis workup activation agglutinin aplastic bandemia calculation
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
- Differential Diagnosis ... Reactive: • Anemia ... /blood loss (Fe ... (malignancy, rheumatologic ... causes #Platelets #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hematologic: Acute blood ... hemolysis, deficiency anemia ... Inflammatory Conditions: Rheumatologic ... #Algorithm #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
the peripheral blood ... (e.g. cancer, infection ... G6PD deficiency), Infections ... Production #Index #hematology ... #diagnosis #calculation
Janeway Lesions in Endocarditis seen on Physical Exam Dr Supradip Ghosh @dr_supradip 36 year old male with history
Blood cultures growing ... His sister shared ... Infective Endocarditis ... could have been diagnosed ... #dermatology #soles
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
anemia • Cold ... Immunoglobulin M (IgM) • Blood ... sensitize red blood ... chills, flank pain ... #hematology #diagnosis
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
- Differential Diagnosis ... Water - Pus - Blood ... Transverse myelitis • Hematology ... : - Anemia • ... Deconditioning - Pain
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... Internal (RBC) - Infections ... Defects: Sickle cell anemia ... - Peripheral Blood ... #hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
of peripheral blood ... Differential Diagnosis ... cultures, including blood ... #differential #diagnosis ... neutrophil #WBC #CBC #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Neutropenia - recurrent infections ... Idiopathic • Infections ... result from low blood ... #oncology #hematology ... #diagnosis #management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... , bleeding, infections ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
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