418 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... immune deficiency, Drugs ... Anti-IFN-y and JAK inhibitors ... #management #treatment
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
Drugs associated ... Antimicrobials Drug-induced ... Tyrosine kinase inhibitors ... panitumumab) #Drugs ... #differential #diagnosis
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Drugs: Direct or ... drugs (e.g. direct ... Inhibitors: Non ... Prolonged #Causes #diagnosis
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Drugs a. ... Direct Xa inhibitors ... Drugs a. ... drugs e.g. direct ... Prolonged #Causes #diagnosis
Summary table of the mechanism of action, side effect and contraindications of commonly used anti-coagulation drugs.
anti-coagulation drugs ... Selective factor Xa inhibitors ... thrombin (factor lla) inhibitors ... comparison #table #management ... #drugs
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
necrosis factor-α inhibitors ... • Injection drug ... characteristic features Clinical ... Tuberculosis Diagnosis ... #Management #Treatment
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... • Direct renin inhibitor ... Angiotensin-converting enzyme (ACE) inhibitors ... • Calcineurin Inhibitors ... #differential #diagnosis
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
necrosis factor-α inhibitors ... • Injection drug ... characteristic features Clinical ... Tuberculosis Diagnosis ... #Management #Treatment
Drugs causing hyperkalemia
 • Impaired release of renin: NSAIDs, Beta blockers, Cyclosporine, tacrolimus, Diabetes, Elderly
 •
Drugs causing hyperkalemia ... Angiotensin-converting enzyme inhibitors ... Drospirenone #Drugs ... #differential #diagnosis
Hyperuricemia - Differential Diagnosis Algorithm
Primary - Over-production
     • Increased turnover of nucleotides
Primary
- Differential Diagnosis ... Hypercalcemia - Drug-Induced ... Antiuricosuric drugs ... • ACE inhibitors ... #Differential #Diagnosis