568 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... immune deficiency, Drugs ... Anti-IFN-y and JAK inhibitors ... #management #treatment ... #summary #rheumatology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Drugs: Direct or ... drugs (e.g. direct ... Prolonged #Causes #diagnosis ... #differential #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Drugs a. ... Drugs a. ... drugs e.g. direct ... Prolonged #Causes #diagnosis ... #differential #hematology
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
Drugs associated ... Antimicrobials Drug-induced ... Tyrosine kinase inhibitors ... panitumumab) #Drugs ... #differential #diagnosis
Drugs Commonly Implicated as Triggers of Drug Induced Thrombocytopenia
#Diagnosis #Hematology #Thrombocytopenia #Differential #DrugInduced #Medications
Drugs Commonly Implicated ... as Triggers of Drug ... Thrombocytopenia #Diagnosis ... #Hematology #Thrombocytopenia
Gout Management in CKD
 • Colchicine
 • NSAID
 • Glucocorticoid
 • ACTH
 • Interleukin-1 Inhibitors

#Gout #Management
Gout Management ... Interleukin-1 Inhibitors ... #Gout #Management ... #CKD #rheumatology
Summary table of the mechanism of action, side effect and contraindications of commonly used anti-coagulation drugs.
anti-coagulation drugs ... Selective factor Xa inhibitors ... thrombin (factor lla) inhibitors ... comparison #table #management ... #drugs
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... • Direct renin inhibitor ... Angiotensin-converting enzyme (ACE) inhibitors ... • Calcineurin Inhibitors ... #differential #diagnosis
Medications for Prevention of Chronic Gout
Colchicine (Colcrys)
Pegloticase (Krystexxa)
Probenecid
Xanthine oxidase inhibitors:
 - Allopurinol (Zyloprim)
 - Febuxostat (Uloric)
#Chronic
Xanthine oxidase inhibitors ... Medications #Treatment #Management ... #AAFP #Rheumatology
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
deficiency, or an inhibitor ... deficiencies and inhibitors ... Patient has a factor inhibitor ... Mixing #Study #diagnosis ... #hematology #laboratory