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differential algorithm transaminitis blood causes dili hematology product reactions aclf aflp aih autoimmune chemistry chronic cirrhosis drug druginduced failure fatty
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... Hepatopathy • Acute ... injury) • Ischemic ... #hepatology #transaminitis
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Liver Injury ... - Drug-Induced liver ... injury - Viral ... #Differential #Hepatology ... #Diagnosis
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... > 20x normal - Acute ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #diagnosis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Injury (DILI) ... Failure #Cirrhosis #Hepatology ... #gastroenterology ... #management #diagnosis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... #differential #Diagnosis ... #Management #gastroenterology ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
: Liver Injury ... Infections: Hepatitis ... #Diagnosis #hepatology ... Transaminitis #LFTs ... #hepatitis
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Diagnosis Hepatocellular ... #Injury #Differential ... #Diagnosis #Causes ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... viral hepatitis ... #chemistry #diagnosis ... #differential #Hepatology ... transaminitis #LFTs
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential Diagnosis ... Liver Injury: ... #injury #hepatitis ... #algorithm #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... dechallenge • Acute ... • Autoimmune hepatitis ... #Injury #Diagnosis ... #Algorithm #hepatology
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