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diagnosis hepatology differential treatment lfts reactions syndrome transaminitis algorithm blood hepatitis indications pathophysiology product rheumatology transfusion aclf aflp aih aki
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... Brain Failure Lung ... Injury (DILI) ... #Failure #Cirrhosis
Indications for Albumin for Management of Cirrhosis • Large volume paracentesis (>5 liter) - 8g per
for Albumin for Management ... of Cirrhosis ... ascites removed • Acute ... kidney injury ( ... #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... • NAFLD • Cirrhosis ... Hepatopathy • Acute ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Liver Injury: ... Liver Injury: ... CA, small cell lung ... hepatitis: < 1 • Cirrhosis
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... Injury Transaminase ... > 20x normal - Acute ... CMV), Alcoholic cirrhosis ... #Injury #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Mixed - Check Acute ... injury < 26 weeks ... hepatitis: < 1 • Cirrhosis ... : > 1 • Acute ... #differential #Hepatology
Hepatorenal Syndrome (HRS) - Diagnostic Criteria HRS-AKI (Acute: previously known as HRS Type 1) • ↑ Creatinine
Criteria HRS-AKI (Acute ... structural kidney injury ... , Normal renal ultrasound ... HRS-NAKI (Non-Acute ... HRSAKI #HRSNAKI #hepatology
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
injury (INR > 2 ... > 3 mg/dL) or acute ... liver failure ... #Indications #management ... #hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... headache, malaise) → Acute ... Antithrombin Ill • Ultrasound ... #Pregnancy #hepatology ... obgyn #diagnosis #management
Outpatient Hypertension Management Algorithm Monotherapy: • Thiazide/thiazide-like • ACE-I (non-black patients), • ARB
Outpatient Hypertension Management ... ARB • CCB (long ... Kidney Injury ... Amy Chung, MD, MSc ... #Hypertension #Management
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