21 results
Cyanide Toxicity 
Treatment:
1) Hydroxocobalamin + Cyanide = Cyanocobalamin (nontoxic) 
   or 
2) Amyl nitrite
Cyanide Toxicity ... Treatment: 1 ... #Cyanide #Toxicity ... #Toxicology #Pathophysiology ... #Management #Treatment
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
tumour causing injury ... Acute #SpinalCord #Injury ... Syndromes #diagnosis #pathophysiology ... #signs #symptoms ... #orthopedics #neurology
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Acidosis (MALA) Pathophysiology ... and acute kidney injury ... also includes symptoms ... LacticAcidosis #Toxicity ... #Toxicology #Diagnosis
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
described phases of toxicity ... caustic mucosal injury ... post-ingestion) - Symptom ... caustic bowel injury ... #Toxicology #Diagnosis
Salicylate Toxicity - Diagnosis and Management

Clinical Findings
Pathophysiology
Workup
Treatment

By Stacy Marshall, MD

#Salicylate #Toxicity #Diagnosis #Management #Toxicology #Aspirin #Treatment
Salicylate Toxicity ... Clinical Findings Pathophysiology ... Workup Treatment ... Diagnosis #Management #Toxicology ... #Aspirin #Treatment
Vancomycin Associated Acute Kidney Injury

 • Drug induced acute kidney injury is generally defined as a
Associated Acute Kidney Injury ... induced acute kidney injury ... • Treatment includes ... #pharmacology #toxicology ... diagnosis #management #nephrology
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... ingestion/exposure Symptoms ... Salicylate #Aspirin #Toxicity ... #Toxicology #diagnosis ... #management #Treatment
Reported Mechanisms and Toxicity of Investigational Treatments for SARS-COV-2
Chloroquine and Hydroxychloroquine
 • Mechanisms: Interference with ligand
Mechanisms and Toxicity ... Investigational Treatments ... hearing loss, GI symptoms ... acidosis, renal injury ... #Toxicology #Medications
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
Induced Muscle Toxicity ... any time during treatment ... Direct muscle injury ... Risk of muscle injury ... Statin #muscle #toxicity
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
: • Triad of symptoms ... urine • Other symptoms ... Treatment: ... Treatment of underlying ... #nephrology