2851 results
One and a Half Syndrome on Physical Exam

This 28 year old patient presented to clinic with
One and a Half Syndrome ... Cogan’s) One and a Half ... one side and an internuclear ... OneAndAHalf #One #Half
Pharmacology of diuretics

Acetazolamide, Loop diuretics, Thiazide‐like diuretics, MRA, Amiloride

Site of Action, Maximum Dose, Half-Life, Onset, Bioavailability,
Maximum Dose, Half-Life ... CHF #Cardiology #Management
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
to transiently halt ... Diabetes Mellitus Half-and-Half
Wall-eyed bilateral inter nuclear ophthalmoplegia (WEBINO) Syndrome

In this specific case, the lesion is bilaterally in the
Walleyed #bilateral #internuclear
One-and-a-Half Syndrome
1 - One eye cannot move AT ALL horizontally
1/2 - The other eye can only
One-and-a-Half Syndrome ... abduct (can do only half ... OneAndAHalf #One #Half
SARS-CoV-2 Estimated Aerosol and Surface Viability:
 - Aerosols: ≈3hrs post aerosolization (median half-life: 1.2 – 1.2hrs)
aerosolization (median half-life ... 2 – 3d (median half-life ... 2 – 3d (median half-life
Metformin in Diabetic Kidney Disease
Immediate release:
 • Initial 500 mg or 850 mg once daily
 •
44: Initiate at half ... titrate upwards to half ... pharmacology #algorithm #management
SSRI Initiation
How long before increasing dose?
 • 4 wks. Initial response in 2-4 wks, max response
GAD-7 Longest half ... Shortest half life ... psychiatry #treatment #management
Amiodarone Toxicity and Monitoring

Tremor Ataxia 
Ocular neuritis 
Corneal Microdeposits 
Bradycardia 
Pulmonary fibrosis 
Hepatotoxicity 
Blue-gray skin
Distribution - Half ... Adverse #Diagnosis #Management
Trichodysplasia spinulosa: follicles plugged w/ hyperkeratotic & parakeratotic debris, excessive inner root sheath differentiation towards keratinization.
EM shows intranuclear