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rheumatology differential summary comparison erythematosus sle systemic ana syndrome activation antibodies arthritis autoantibodies bleeding bruising coagulation common compared cvid deficiencies
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... • +ANA can be seen ... Kumfer @AnnKumfer #Antinuclear ... ANA #patterns #rheumatology ... #diagnosis #differential
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Can also be measured ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... #SLE #Summary #diagnosis ... #rheumatology # ... management
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
of Factor IX Acquired ... Acute DIC - Septic shock ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Manifestations: - CRP ... Evolution: Chronic disease ... Erythematosus #Diagnosis ... #rheumatology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... Bleeding gums can ... inhibitor and lupus ... #Differential #Diagnosis ... #Hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Usual therapeutic management ... Evolution: Chronic disease ... sle #comparison #table ... #rheumatology # ... diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
the secondary or acquired ... • Systemic lupus ... SJIA], systemic lupus ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
-> 40 years • Can ... severe community-acquired ... and M panel Management ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... angioedema • vWD • acquired ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Differential #Diagnosis
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