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rheumatology erythematosus systemic treatment comparison activation ana antinuclear autoantibodies cardiology cardiomyopathy classification coagulation cryoglobulinemia cryoglobulins deficiencies deficiency druginduced hemophagocytic hlh
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
of Factor IX Acquired ... RA, SLE), Post-partum ... Acute DIC - Septic shock ... #table #comparison ... #diagnosis #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Summary • Epidemiology ... : Chronic disease ... #Management #Summary ... #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... #Summary #diagnosis ... #rheumatology # ... management
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... Can also be measured ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Manifestations: - CRP ... Usual therapeutic management ... : Chronic disease ... #table #rheumatology ... #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
the secondary or acquired ... • Systemic lupus ... erythematosus [SLE ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Polycythemia Vera (PV) - Diagnosis and Management Summary Diagnostic Criteria: • Elevated hemoglobin and/or hematocrit AND •
Summary Diagnostic ... with evidence of acquired ... von Willebrand disease ... #Management #Summary ... #treatment #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Purtilo (XLP) Acquired ... : SLE+++, Adult-onset ... Still disease, ... #management #treatment ... #summary #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia Summary ... • Autoimmune diseases ... : - 10% SLE or ... Labs/Diagnosis: ... (e.g. systemic lupus
Peripartum Cardiomyopathy - Summary 1. Definition • Towards the end of pregnancy to 5 months postpartum
Cardiomyopathy - Summary ... Differential Diagnosis ... orthopnea, PND, LE ... Pts: cardiogenic shock ... Delivery • Stable
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