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rheumatology lupus associations comparison druginduced erythematosus management systemic ana antibodies antinuclear cutaneous dermatology dil diseases endocarditis eschar infective marantic mucormycosis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... hepatitis Anti-CCP ... Anti-Jo-1 - Polymyositis ... Associations #diseases #diagnosis ... #table #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in ... Lupus (SLE): ANA ... Myositis: Anti-JO-1, ... diagnosis #associations ... #table
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... months) and of autoantibodies ... #comparison #table ... #rheumatology # ... diagnosis #management
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
is clinically suspected ... syndromes Anti-PCNA 1- ... #Antinuclear #autoantibodies ... erythematosus #diagnosis ... table #ANA
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... • Anti-Ro/SSA autoantibodies ... Differential Diagnosis ... • ANA titers > 1: ... Ro/La, anti-Jo-1,
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
can only be confirmed ... suspicion is required ... conditions: Autoimmune (SLE ... often small (<1 ... #table
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
to 1:1 F:M • Clinical ... is rare in DIL, SCLE-DIL ... Manifestations: - CRP ... months) and of autoantibodies ... #diagnosis #treatment
Cutaneous Mucormycosis Eschar 30 M HIV cd4 10 VL 30k traumatic injury of arm few months ago
Diagnosis? ... immunosuppressed pts: usually acquired ... malnutrition, HIV, SLE ... #skin #clinical ... #photo
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