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Table of Causes of Acute Liver Injury
#Diagnosis #Hepatology #Acute #Liver #Injury #Causes #Differential #Incidence #Table #Failure
Table of Causes ... of Acute Liver Injury ... #Diagnosis #Hepatology ... #Acute #Liver # ... Injury #Causes #
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... Diagnosis Hepatocellular ... Hepatic Artery: Shock ... #Causes #Acute
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
of Factor IX Acquired ... Liver Disease - Alcohol ... DIC - Septic shock ... #comparison #diagnosis ... #hematology #deficiency
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... - Differential Diagnosis ... Algorithm Vascular Causes ... Hepatic artery: Shock ... ALT Ratios: • Alcoholic
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
Diagnostic Framework ... kidney disease, Acute ... patients), "Hospital-acquired ... independent of alcohol ... #causes #hematology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Failure Infections Alcohol-Associated ... Drug-Induced Liver Injury ... gastroenterology #management #diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... for alternative causes ... HEV, EBV, CMV), Alcohol-related ... dechallenge • Acute ... #hepatology
Hepatorenal Syndrome (HRS) - Diagnostic Criteria
HRS-AKI (Acute: previously known as HRS Type 1)
 • ↑ Creatinine
Syndrome (HRS) - Diagnostic ... Criteria HRS-AKI (Acute ... 20% HAS) • No shock ... structural kidney injury ... HRS-NAKI (Non-Acute
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
liver or renal injury ... ->treatments include ... cardiac output - Acute ... peritonitis - Acute ... Hypoglycemia - Alcohol
Alcoholic Hepatitis - Management Algorithm
Assess Eligibility for Treatment:
 - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... exclude other causes ... : - Acute kidney ... injury with serum ... Multiorgan failure or shock