11 results
diagnosis management algorithm differential causes injury coagulation hepatitis anemia chemistry chronic cirrhosis comparison deficiencies deficiency dic dili disseminated druginduced failure
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Failure Infections Alcohol-Associated ... #Acute #Chronic ... #Cirrhosis #Hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... HSV • Toxic: Alcohol ... Hepatic Artery: Shock ... Medication, Pregnancy, Alcoholic ... #algorithm #hepatology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
of Factor IX Acquired ... ) • Advanced Liver ... Disease - Alcohol ... DIC - Septic shock ... comparison #diagnosis #hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
kidney disease, Acute ... patients), "Hospital-acquired ... use, Liver disease ... independent of alcohol ... diagnosis #causes #hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Hepatic artery: Shock ... VZV • Trauma: Shock ... ALT Ratios: • Alcoholic ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Hepatocellular - Check Acute ... Mixed - Check Acute ... ALF): • Liver ... ALT Ratios: • Alcoholic ... #differential #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... non-essential drug/HDS treatments ... HEV, EBV, CMV), Alcohol-related ... dechallenge • Acute ... Diagnosis #Algorithm #hepatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
excessive macrophage activation ... presents as an acute ... lymph node, or liver ... • Bicytopenia Treatment ... #hematology
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... : - Acute kidney ... HCV, DILI, HCC, acute ... Multiorgan failure or shock ... Management #Algorithm #hepatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
malignancy (Especially acute ... dysfunction (16%) • Shock ... DIC • Severe Liver ... + Bleeding Treatment ... #management #hematology
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