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differential management algorithm causes hepatitis lfts transaminitis acute classification coagulation gastroenterology syndrome workup acidosis activation aih anemia arterial autoimmune bacterial
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
months without treatment ... Failure Infections Alcohol-Associated ... Injury (DILI) ... Failure #Cirrhosis #Hepatology ... gastroenterology #management #diagnosis
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... Diagnosis Hepatocellular ... HSV • Toxic: Alcohol ... Hepatic Artery: Shock ... Acute #algorithm #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
- Differential Diagnosis ... injury) • Ischemic ... Hepatopathy (shock ... #Differential #Diagnosis ... #hepatology #transaminitis
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... Injury Transaminase ... #Patterns #Liver ... #Injury #hepatology ... #differential #diagnosis
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
of Factor IX Acquired ... ) • Advanced Liver ... Disease - Alcohol ... Acute DIC - Septic shock ... #hematology #deficiency
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Diagnosis Framework ... : Liver Injury ... Diagnosis: • ... Drugs (MDMA), Alcohol ... #Diagnosis #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential Diagnosis ... Hepatic artery: Shock ... ALT Ratios: • Alcoholic ... #algorithm #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... non-essential drug/HDS treatments ... HEV, EBV, CMV), Alcohol-related ... #Injury #Diagnosis ... #Algorithm #hepatology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Diagnostic Framework ... patients), "Hospital-acquired ... use, Liver disease ... independent of alcohol ... #causes #hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Failure (ALF): ... • Liver injury ... ALT Ratios: • Alcoholic ... #chemistry #diagnosis ... #differential #Hepatology
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