11 results
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
of Factor IX Acquired ... Liver Disease - Alcohol ... Acute DIC - Septic shock ... comparison #diagnosis #hematology ... #deficiency
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
patients), "Hospital-acquired ... , Folate deficiency ... Non-megaloblastic: Alcohol ... independent of alcohol ... diagnosis #causes #hematology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
->treatments include ... malignancy, or thiamine deficiency ... before beginning treatment ... effect - Thiamine deficiency ... Hypoglycemia - Alcohol
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Purtilo (XLP) Acquired ... Cellular immune deficiency ... Unknown cause Treatment ... diagnosis #management #treatment ... #summary #rheumatology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
anemia, GATA2 deficiency ... , CTLA4 deficiency ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
dysfunction (16%) • Shock ... thrombopoietin deficiency ... + Bleeding Treatment ... diagnosis #causes #treatment ... #management #hematology
Scurvy (Vitamin C Deficiency) - Diagnosis and Management

Vitamin C is required for hydroxylation of proline residues
Scurvy (Vitamin C Deficiency ... Vitamin C is required ... , persons with alcohol ... : • Vitamin C deficiency ... vasculitis Treatment
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
or folic acid deficiency ... arsenic compounds, alcohol ... • Copper deficiency ... Syndromes #diagnosis #hematology ... #oncology
Alcoholic Hepatitis - Management Algorithm
Assess Eligibility for Treatment:
 - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... Eligibility for Treatment ... Multiorgan failure or shock ... prednisolone #Alcoholic ... Management #Algorithm #hepatology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Pain in LN on alcohol ... Hodgkin Lymphoma Treatment ... classification #hematology ... #oncology #management