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C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook

Clinical Presentation + Progression:
Difficile Infection ... Toxic Megacolon, Shock ... can be community-acquired ... Ileus, Megacolon, Shock ... ciab549 #CDI #Cdiff
Causes of Antibiotic Failure - Differential Diagnosis Framework
Diagnosis:
 • Non-Infectious: Malignant, Autoimmune, Drug-related (NMS, serotonin syndrome,
Framework Diagnosis ... NMS, serotonin syndrome ... Immunocompromise Treatment ... • Secondary to Treatment ... (C diff) • Hospital-Acquired
Shock - Differential Diagnosis Framework
 - MAP <65. SBP <90, drop in SBP > 40
 -
Diagnosis Framework ... Cardiogenic: Myocardial Infarction ... Abdominal compartment syndrome ... Treatment Goals ... #Differential #Diagnosis
Streptococcal Toxic Shock Syndrome (STSS)
Complication of invasive GAS disease characterized by shock & MOF → occurs
Syndrome (STSS) ... 50% in nec fasc Diagnostic ... day 2 + 3 BIDMC Infectious ... #Syndrome #STSS ... #diagnosis
Orthopedic Emergencies
Compartment Syndrome
 • An increase in compartment pressure to the point where tissue perfusion is
progressive inflammatory infection ... • Diagnosis: ... including DM • Treatment ... #Emergencies #diagnosis ... #management #treatment
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
Preeclampsia, Eclampsia, Infection ... /Sepsis/Shock, Autoimmune ... : • Infection, ... epilepticus Treatment ... underlying cause • Treatment
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
Guillain-Barré Syndrome ... to a preceding infection ... and cauda equina TREATMENT ... ventilation is required ... Guillain #Barre #Syndrome
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
disequilibrium syndrome ... • Diagnosis of ... Acute myocardial infarction ... • Hypovolemic shock ... Tolvaptan) • Treatment
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation Syndrome ... the secondary or acquired ... SLE], AOSD) • Infection ... Treatment: • Corticosteroids ... #Diagnosis #Management
IDSA - Approach to Treating a Patient With Diabetic Foot Osteomyelitis
When to consider a trial of
IDSA - Approach ... of nonsurgical treatment ... 48–72 h if on treatment ... not otherwise required ... Persistent sepsis syndrome