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diagnosis erythematosus lupus management sle vasculitis disease myositis workup agglutinin ana anemia antibodies antinuclear arteritis arthritis autoantibodies behcet causes champs
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... weakness, less systemic ... symptoms, and less ... anti-synthetase syndrome ... Myositis #diagnosis #rheumatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
autoimmune disease ... skin thickening Signs ... and Symptoms: ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... Wiskott-Aldrich syndrome ... Inflammatory and Autoimmune ... Diseases: • Systemic ... #Diagnosis #Hematology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Atypical HUS, autoimmune ... antiphospholipid syndrome ... glomerulonephritis (>90%) S - Systemic ... Mnemonic #diagnosis #differential ... #hematology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features of Systemic ... Demyelinating syndromes ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... SLE), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... ANA #patterns #rheumatology ... #diagnosis #differential
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Eosinophilia - Differential ... (vasculitis / autoimmune ... Lymphomas - Systemic ... Hypereosinophilic Syndrome ... Diagnosis #Causes #hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... autoantibodies #signs ... #symptoms #mimickers ... #differential # ... rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Systemic disease ... meningitis), MCC CNS symptoms ... Behcet disease) Differential ... diagnosis #management #signs ... #symptoms #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral infection, autoimmune ... CLL (older) • Autoimmune ... younger pts) Differential ... hemolytic #anemia #hematology
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