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differential erythematosus lupus systemic causes leukemia oncology thrombocytopenia vasculitis workup agglutinin algorithm autoantibodies chronic classification cold disease disorders lymphocytic mimickers
Pathophysiology, Signs and Symptoms of Hemolytic Anemia #Pathophysiology #Hemolytic #Anemia #hematology #diagnosis #signs #symptoms
Signs and Symptoms ... of Hemolytic Anemia ... #Hemolytic #Anemia ... #hematology #diagnosis ... #signs #symptoms
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Autoimmune • ITP • SLE ... • CLL • APLA ... Non-lmmune: • HELLP Syndrome ... Algorithm #Causes #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Sensitive Antibodies ... Cold Agglutinin Syndrome ... Diagnosis: • hemolytic ... anemia • Cold ... #anemia #hematology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
of hip (rare), Arthritis ... ) Blood (75%): Anemia ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Manifestations: - Arthritis ... anemia 4% - Myositis ... Auto-Antibodies ... autoantibodies #signs ... #differential #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
ALL Symptoms: ... - infiltrates (anemia ... ) CLL Symptoms: ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... with no early symptoms ... Physical Exam/Signs ... • Neutropenia, anemia ... workup #oncology #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Non-autoimmune rheumatologic ... lymphopenia, low PLT • Anemia ... Induced Lupus: • Symptoms ... #Rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
pylori test (GI symptoms ... test, ANA (e.g., SLE ... anti-phospholipid antibodies ... changes), high MCV anemia ... Causes #Workup #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Presentation - Systemic Symptoms ... purpura: strong sign ... C-ANCA) pattern: antibodies ... vasculitis, and SLE ... #rheumatology #
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