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diagnosis liver differential management hepatitis transaminitis aclf acute alcoholic chronic cirrhosis drug druginduced failure function hemochromatosis hepatocellular idiosyncratic induced liverenzymes
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
dose dependent injury ... Chronic - ongoing ↑ LFTs ... Diagnosis #Management #gastroenterology ... #algorithm #gastroenterology ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... for alternative causes ... disease, Hepatic ischaemia ... disorder (e.g. ascites ... #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Function Tests (LFTs ... (>1000): • DILI ... Drug-induced liver injury ... ) • Ischemic Hepatopathy ... Differential #Diagnosis #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
months without treatment ... Drug-Induced Liver Injury ... (DILI) Viral Hepatitis ... Failure #Cirrhosis #Hepatology ... #gastroenterology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Differential Diagnosis Algorithm ... Drugs/Toxins • Ischemia ... • Others #LFTs ... #Hepatology #LiverEnzymes ... #Causes
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver Injury ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... • Iatrogenic: DILI ... differential #diagnosis #algorithm ... #hepatology
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
exclude other causes ... blood, urine and ascites ... - Acute kidney injury ... HCV, DILI, HCC, ... #hepatology
Portal Vein Thrombosis (PVT) Treatment Algorithm - If concern for ischemic: anti-coag+multidisciplinary care - W/o cirrhosis+recent
Algorithm - If ... concern for ischemic ... - Cirrhosis: case-by-cased ... #management #Algorithm ... #hepatology
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. Step 1: In the patient with
Algorithm regarding ... diagnosis and treatment ... hemochromatosis #algorithm ... diagnosis #management #hepatology ... #gastroenterology
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