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hepatology injury transaminitis rheumatology causes dermatology dili hepatitis vasculitis abnormal arthritis chemistry classification color disease drug druginduced eczematous elevated em
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
> 20x normal - Acute ... 5-10x normal - Chronic ... #LFTs #transaminitis ... #differential # ... diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Differential Diagnosis ... Cirrhosis • Chronic ... Hepatopathy • Acute ... injury) • Ischemic ... Diagnosis #hepatology
Mesenteric Ischemia - Differential Diagnostic Schema Chronic: ASCVD, Venous, Vasculitides 5% (PAN, [E]GPA, IgA, MPA) Acute - Venous
Diagnostic Schema ... Chronic: ASCVD, ... GPA, IgA, MPA) Acute ... #Schema #Differential ... #Diagnosis #algorithm
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Diagnosis Algorithm ... Drugs/Toxins • Ischemia ... • Others #LFTs ... Diagnosis #Algorithm
Differential Diagnosis and Evaluation of Hyponatremia: 1) Identification of onset (acute vs. chronic) 2) Presence of symptoms (HA,
Differential Diagnosis ... Identification of onset (acute ... vs. chronic) 2) ... history (cardiac, liver ... #Algorithm #Ddxof
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Diagnosis Framework ... • Vascular: Ischemic ... #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... presentation • Chronic ... - ongoing ↑ LFTs ... Idiosyncratic #differential ... gastroenterology #algorithm
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... , Chronic viral ... #chemistry #diagnosis ... #differential # ... #LFTs #RValue #
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Diagnosis Algorithm ... Drugs, Viral, Ischemia ... #diagnosis #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... Algorithm DILI ... disease, Hepatic ischaemia ... dechallenge • Acute ... #Algorithm #hepatology
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