13 results
diagnosis differential injury lfts transaminitis causes management aclf albumin anemia ascites chemistry cirrhosis dehydrogenase dili druginduced elevated failure function gastroenterology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... 20x normal - Acute ... 5-10x normal - Chronic ... #Patterns #Liver ... #Injury #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Circulation Failure Kidney ... Failure Infections Alcohol-Associated ... #Chronic #Liver ... Failure #Cirrhosis #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Skin involvement, Kidney ... HEV, EBV, CMV), Alcohol-related ... Hepatic ischaemia ... dechallenge • Acute ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... HSV • Toxic: Alcohol ... , Acute biliary ... Medication, Pregnancy, Alcoholic ... #algorithm #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Cirrhosis • Chronic ... Viral Hepatitis ... Hepatopathy • Acute ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • NAFLD • Alcohol ... hepatitis • Drugs ... Others #LFTs #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... ALT Ratios: • Alcoholic ... > 2 • NASH, Chronic ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
viral hepatitis ... ALT Ratios: • Alcoholic ... > 2 • NASH, Chronic ... injury: > 3 • Chronic ... #differential #Hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
kidney disease, ... Acute blood loss ... use, Liver disease ... independent of alcohol ... diagnosis #causes #hematology
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