12 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
20x normal - Acute ... Infection (EBV/CMV), Alcoholic ... AST:ALT > 2.5 - Alcoholic ... Liver #Injury #hepatology ... #LFTs #transaminitis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Hepatopathy • Acute ... Viral Hepatitis ... liver injury) • Ischemic ... Differential #Diagnosis #hepatology ... #transaminitis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Differential Diagnosis Algorithm ... for Transaminitis ... Drugs, Viral, Ischemia ... - NAFLD, Alcohol ... #hepatology #LiverFunctionTests
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Differential Diagnosis Algorithm ... Drugs/Toxins • Ischemia ... • NAFLD • Alcohol ... hepatitis • Drugs ... Others #LFTs #Hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... HSV • Toxic: Alcohol ... , Acute biliary ... Medication, Pregnancy, Alcoholic ... #algorithm #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
HEV, EBV, CMV), Alcohol-related ... disease, Hepatic ischaemia ... dechallenge • Acute ... disorder (e.g. ascites ... #hepatology
Causes of Ascites
Normal Peritoneum
Portal hypertension (SAAG > 1.1 g/dL)
  1. Hepatic congestionl
Causes of Ascites ... Cirrhosis - Alcoholic ... hepatitis ... fibrosis - Acute ... #differential #hepatology
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis
High albumin gradient (>1.1 g/dl):
 - Cirrhosis	
 - Alcoholic
Cirrhosis - Alcoholic ... hepatitis - Cardiac ... Veno-occlusive disease - Acute ... associated with bowel ischemia ... Differential #Diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
viral hepatitis ... viral hepatitis ... ALT Ratios: • Alcoholic ... #differential #Hepatology ... #transaminitis