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diagnosis differential causes injury liver lfts transaminitis management acute ah criteria dili druginduced elevated extravascular hearingloss hematology hemolysis hepatocellular hepatomegaly
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Drugs/Toxins • Ischemia ... • Autoimmune ... • Drugs • AIH ... hepatitis • Drugs ... Others #LFTs #Hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
- Ischemic Hepatitis ... Infection (EBV/CMV), Alcoholic ... AST:ALT > 2.5 - Alcoholic ... , Ischemic Necrosis ... Liver #Injury #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Differential Diagnosis Algorithm ... Drugs, Viral, Ischemia ... - NAFLD, Alcohol ... #diagnosis #hepatology
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Differential Diagnosis Algorithm ... Inflammatory • Alcoholic ... Hepatitis • Autoimmune ... Differential #Diagnosis #Algorithm ... #Causes #Hepatology
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
Clinical Diagnosis of Autoimmune ... Hepatitis - Onset ... factors - Possible ischemic ... SMA >1:80 #Autoimmune ... #Hepatology #AIH
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
Hepatitis (AH) ... factors • Possible ischemic ... hepatitis (e.g. ... #Hepatitis #AH ... #hepatology #criteria
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
HSV • Toxic: Alcohol ... Other: NAFLD, Autoimmune ... Medication, Pregnancy, Alcoholic ... Causes #Acute #algorithm ... #hepatology
Alcoholic Hepatitis - Management Algorithm 1. Severity assessed not only by MDF (>32) but also by MELD
Alcoholic Hepatitis ... - Management Algorithm ... survival in severe AH ... #Algorithm #treatment ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... Other: NAFLD, Autoimmune ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... upper limit of normal ... BryanCUlrich #Autoimmune ... #Hepatitis #AIH ... Diagnosis #Management #Hepatology
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