20 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... 5-10x normal - Chronic ... #Patterns #Liver ... #Injury #hepatology ... transaminitis #differential
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • Drugs • AIH ... hepatitis • Drugs ... Others #LFTs #Hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... Cirrhosis • Chronic ... Viral Hepatitis ... injury) • Ischemic ... #Diagnosis #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Drugs, Viral, Ischemia ... kwburak #LFTs #Elevated ... #diagnosis #hepatology
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
Hepatitis (AH) ... factors • Possible ischemic ... ) or metabolic liver ... #Hepatitis #AH ... #hepatology #criteria
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Injury - Differential ... HSV • Toxic: Alcohol ... #Injury #Differential ... Causes #Acute #algorithm ... #hepatology
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Hepatomegaly - Differential ... Diagnosis Algorithm ... Non-Malignant • Fatty Liver ... Inflammatory • Alcoholic ... #Causes #Hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
Elevated Transaminases ... Transaminitis - Differential ... Trauma: Shock liver ... See Updated Schema ... Diagnosis #causes #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Failure Infections Alcohol-Associated ... Hepatitis (AAH) ... #ACLF #Acute #Chronic ... #Cirrhosis #Hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis