15 results
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Severe Acute Liver Injury ... - Ichemic hepatitis ... - Autoimmune ... -1 antitrypsin deficiency ... #Differential #Hepatology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver Injury ... Infection (EBV/CMV), Alcoholic ... AST:ALT > 2.5 - Alcoholic ... Patterns #Liver #Injury ... #hepatology #LFTs
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
Hepatitis (AH) ... factors • Possible ischemic ... I antitrypsin deficiency ... #Hepatitis #AH ... #hepatology #criteria
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Drugs/Toxins • Ischemia ... • Autoimmune ... • AIH • A1AT deficiency ... hepatitis • Drugs ... Others #LFTs #Hepatology
Alcoholic Hepatitis - Management Algorithm
1. Severity assessed not only by MDF (>32) but also by MELD
Alcoholic Hepatitis ... - Management Algorithm ... survival in severe AH ... #Algorithm #treatment ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
of Acute Liver Injury ... HSV • Toxic: Alcohol ... Other: NAFLD, Autoimmune ... Causes #Acute #algorithm ... #hepatology
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Differential Diagnosis Algorithm ... Inflammatory • Alcoholic ... HepatitisAutoimmune ... Differential #Diagnosis #Algorithm ... #Causes #Hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... Other: NAFLD, Autoimmune ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Inflammation - Hepatitis ... Schistosomiasis - Autoimmune ... Sarcoidosis Toxic - Alcohol ... α1-antitrypsin deficiency ... #Differential #Hepatology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis of Autoimmune ... factors - Possible ischemic ... 1 antitrypsin deficiency ... SMA >1:80 #Autoimmune ... #Hepatology #AIH