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diagnosis differential causes injury liver transaminitis acute abnormal ah aih anemia cirrhosis coagulation comparison criteria deficiencies dili druginduced elevated hepatocellular
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Drugs/Toxins • Ischemia ... • Autoimmune ... hepatitis • Drugs ... • Others #LFTs ... #Hepatology #LiverEnzymes
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
> 50x normal - Ischemic ... Infection (EBV/CMV), Alcoholic ... AST:ALT > 2.5 - Alcoholic ... Liver #Injury #hepatology ... #LFTs #transaminitis
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Liver Injury - Ichemic ... hepatitis - Acute ... - Autoimmune ... -1 antitrypsin deficiency ... #Differential #Hepatology
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Differential Diagnosis Algorithm ... Inflammatory • Alcoholic ... Hepatitis • Autoimmune ... Differential #Diagnosis #Algorithm ... #Causes #Hepatology
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Inflammation - Hepatitis ... Schistosomiasis - Autoimmune ... Sarcoidosis Toxic - Alcohol ... α1-antitrypsin deficiency ... #Differential #Hepatology
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 Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... Other: NAFLD, Autoimmune ... Differential #Diagnosis #hepatology ... #LFTs #hepatitis
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
Hepatitis (AH) ... factors • Possible ischemic ... hepatitis (e.g. ... I antitrypsin deficiency ... #hepatology #criteria
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
Clinical Diagnosis of Autoimmune ... factors - Possible ischemic ... 1 antitrypsin deficiency ... SMA >1:80 #Autoimmune ... #Hepatology #AIH
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Liver Disease - Alcohol ... , Viral hepatitis ... , Autoimmune • ... - Malignancy, Autoimmune ... comparison #diagnosis #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... - Extrinsic: Autoimmune ... Liver disease, Alcoholism ... #Anemia #MCV #Algorithm ... Differential #Diagnosis #hematology
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