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diagnosis liver differential lfts management transaminitis acute causes aih chemistry cirrhosis dili druginduced failure gastroenterology hepatocellular interpretation liverenzymes patterns rvalue
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... 5-10x normal - Chronic ... AST:ALT > 2.5 - Alcoholic ... Patterns #Liver #Injury ... #hepatology #LFTs
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Failure Infections Alcohol-Associated ... Drug-Induced Liver Injury ... Failure #Cirrhosis #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... HEV, EBV, CMV), Alcohol-related ... disease, Hepatic ischaemia ... steatosis • Autoimmune ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Drugs/Toxins • Ischemia ... • Autoimmune ... • NAFLD • Alcohol ... hepatitis • Drugs ... Others #LFTs #Hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
of Acute Liver Injury ... HSV • Toxic: Alcohol ... Other: NAFLD, Autoimmune ... Causes #Acute #algorithm ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... Other: NAFLD, Autoimmune ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... : Autoimmune hepatitis ... ALT Ratios: • Alcoholic ... : > 3 • Chronic ... #hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... - Symptoms of chronic ... pattern of liver injury ... regarding need for treatment ... Diagnosis #Management #Hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Failure (ALF ... ALT Ratios: • Alcoholic ... > 2 • NASH, Chronic ... : > 3 • Chronic ... #differential #Hepatology
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... - Management Algorithm ... - Acute kidney injury ... #Hepatitis #Management ... #Algorithm #hepatology
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