9 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
normal - Infection (EBV ... /CMV), Alcoholic ... AST:ALT > 2.5 - Alcoholic ... Liver #Injury #hepatology ... #LFTs #transaminitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Drugs/Toxins • Ischemia ... hepatitis • Drugs ... • Others #LFTs ... #Hepatology #LiverEnzymes ... #Causes
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
for alternative causes ... , HBV, HCV, HEV, ... EBV, CMV), Alcohol-related ... disease, Hepatic ischaemia ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... : Alcohol, Medication ... Medication, Pregnancy, Alcoholic ... #Acute #algorithm ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Chemistries - Interpretation ... of LFTs R-value ... ALT Ratios: • Alcoholic ... #differential #Hepatology ... transaminitis #LFTs
Sensorineural Hearing Loss - Differential Diagnosis Algorithm

Asymmetric Sensorineural Hearing Loss: 
 • Neoplastic (Vestibular Schwannoma)
 •
Toxoplasmosis, HIV ... , Syphilis, Hepatitis ... Teratogenic drugs, Alcohol ... Cardiovascular Ischemia ... #Causes
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... , HBV, HCV, HEV, ... ALT Ratios: • Alcoholic ... #hepatology
Alcoholic Hepatitis - Management Algorithm
Assess Eligibility for Treatment:
 - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... - Management Algorithm ... exclude other causes ... #Hepatitis #Management ... #Algorithm #hepatology