9 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... normal - Infection (EBV ... 5-10x normal - Chronic ... #Injury #hepatology ... #LFTs #transaminitis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
, HBV, HCV, HEV, ... EBV, CMV), Alcohol-related ... Hepatic ischaemia ... ), Chronic hepatitis ... #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... Tests (LFTs) - ... Cirrhosis • Chronic ... injury) • Ischemic ... #Diagnosis #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... hepatitis • Drugs ... • Others #LFTs ... #Hepatology #LiverEnzymes
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Differential Diagnosis Algorithm ... Drugs, Viral, Ischemia ... Burak @kwburak #LFTs ... #diagnosis #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Differential Diagnosis Algorithm ... , HBV, HCV, HEV, ... Tests of synthetic function ... ALT Ratios: • Alcoholic ... #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... ALT Ratios: • Alcoholic ... > 2 • NASH, Chronic ... #differential #Hepatology ... transaminitis #LFTs
Alcoholic Hepatitis - Management Algorithm
Assess Eligibility for Treatment:
 - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... - Management Algorithm ... Maddrey Discriminant Function ... blood, urine and ascites ... #Algorithm #hepatology