9 results
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
• Infectious: HAV ... , HCV, HEV, EBV, ... HSV, CMV • Neoplasm ... • Iatrogenic: DILI ... Diagnosis #causes #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... Viral infections (HAV ... , HBV, HCV, HEV, ... disease, Hepatic ischaemia ... #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
Chronic Hepatitis ... Chronic Hepatitis ... #HepatitisB #HBV ... #Management #Treatment ... #Hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Cirrhosis • Chronic ... (>1000): • DILI ... liver injury) • Ischemic ... Differential #Diagnosis #hepatology ... #transaminitis
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
> 50x normal - Ischemic ... normal - Infection (EBV ... 5-10x normal - Chronic ... Liver #Injury #hepatology ... #LFTs #transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
• Infectious: HAV ... , HBV, HCV, HEV, ... EBV, HSV, CMV, ... • Iatrogenic: DILI ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
CMV, HSV, VZV ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Alcoholic Hepatitis - Management Algorithm
Assess Eligibility for Treatment:
 - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... diseases including HBV ... HCV, DILI, HCC, ... HIV, TB - Multiorgan ... #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... serologies, HCV ... serologies, HCV ... #differential #Hepatology ... #transaminitis