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diagnosis injury transaminitis causes lfts management saag aflp albumin alcoholic chemistry druginduced elevated function gradient hepatocellular hypertension interpretation obgyn obstetrics
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... Hepatic ischaemia ... dechallenge • Acute ... disorder (e.g. ascites ... #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Transaminitis - Differential ... Trauma: Shock liver ... • Iatrogenic: DILI ... See Updated Schema ... Diagnosis #causes #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Hepatopathy • Acute ... Viral Hepatitis ... (>1000): • DILI ... injury) • Ischemic ... #Diagnosis #hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... develops (DIC, ascites ... infiltration) Differential ... Diagnosis: Viral Hepatitis ... #hepatology #obstetrics
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... , HBV, HCV, HEV, ... • Iatrogenic: DILI ... #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... 20x normal - Acute ... normal - Infection (EBV ... #Injury #hepatology ... transaminitis #differential
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... , Acute biliary ... #Injury #Differential ... #algorithm #hepatology
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis High albumin gradient (>1.1 g/dl): - Cirrhosis - Alcoholic
- Alcoholic hepatitis ... Veno-occlusive disease - Acute ... fatty liver of ... associated with bowel ischemia ... #Diagnosis #hepatology
Causes of Ascites Normal Peritoneum Portal hypertension (SAAG > 1.1 g/dL) 1. Hepatic congestionl
- Alcoholic hepatitis ... fibrosis - Acute ... fatty liver of ... Causes #diagnosis #differential ... #hepatology #SAAG
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... • Vascular: Ischemic ... #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
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