11 results
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... Hepatic ischaemia ... dechallenge • Acute ... disorder (e.g. ascites ... #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... develops (DIC, ascites ... Diagnosis: Viral Hepatitis ... #Liver #Pregnancy ... #hepatology #obstetrics
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... 20x normal - Acute ... normal - Infection (EBV ... #Injury #hepatology ... transaminitis #differential
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis
High albumin gradient (>1.1 g/dl):
 - Cirrhosis	
 - Alcoholic
- Alcoholic hepatitis ... Veno-occlusive disease - Acute ... fatty liver of ... pregnancy - Myxedema ... #Diagnosis #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... Toxic: Medication, Pregnancy ... #Injury #Differential ... #algorithm #hepatology
Causes of Ascites
Normal Peritoneum
Portal hypertension (SAAG > 1.1 g/dL)
  1. Hepatic congestionl
- Alcoholic hepatitis ... fibrosis - Acute ... fatty liver of ... pregnancy 3. ... #hepatology #SAAG
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... - Differential ... , HBV, HCV, HEV, ... melanoma, myeloma • Pregnancy ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... • Vascular: Ischemic ... #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
and hemorrhage Acute ... Fatty Liver of ... #hepatology #obstetrics ... #hepatitis #comparison ... #differential #
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
• Cirrhosis/acute ... hepatitis • Infiltrative ... metastasis • Fatty ... liver of pregnancy ... Diagnosis #causes #hepatology