12 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Hepatitis > ... , Toxic Hepatitis ... Liver #Injury #hepatology ... #LFTs #transaminitis ... #differential #diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... Chronic Viral Hepatitis ... • Acute Viral Hepatitis ... liver injury) • Ischemic ... #hepatology #transaminitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • Drugs • AIH ... • Alcoholic hepatitis ... • Others #LFTs
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
Elevated Transaminases ... • Autoimmune hepatitis ... See Updated Schema ... Transaminases #hepatitis ... #causes #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
- Differential Diagnosis ... Drugs, Viral, Ischemia ... Burak @kwburak #LFTs ... #Elevated #Abnormal ... #diagnosis #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... • Vascular: Ischemic ... #hepatology #algorithm ... Transaminitis #LFTs ... #hepatitis
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Autoimmune Hepatitis ... , AIH diagnosis ... Other Etiology of Hepatitis ... #Autoimmune #Hepatitis ... #AIH #Diagnosis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Check Acute viral hepatitis ... Check Acute viral hepatitis ... specificity to elevated ... Chronic viral hepatitis ... #differential #Hepatology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
of Autoimmune Hepatitis ... hepatitis (e.g. ... #Autoimmune #Hepatitis ... #Diagnosis #Hepatology ... #AIH
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
of Alcoholic Hepatitis ... factors • Possible ischemic ... hepatitis (e.g. ... #Hepatitis #AH ... #hepatology #criteria