24 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Hepatitis > ... - Acute Viral Hepatitis ... , Toxic Hepatitis ... Liver #Injury #hepatology ... #LFTs #transaminitis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... Chronic Viral Hepatitis ... • Acute Viral Hepatitis ... liver injury) • Ischemic ... Differential #Diagnosis #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • Cholestatic disease ... • Alcoholic hepatitis ... • Others #LFTs
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
hepatitis - Acute ... injury - Viral Hepatitis ... - Autoimmune hepatitis ... - Wilson disease ... #Differential #Hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
Elevated Transaminases ... Metabolic: Wilson Disease ... • Autoimmune hepatitis ... Transaminases #hepatitis ... Diagnosis #causes #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Infectious • Hepatitis ... • Alcoholic Hepatitis ... • Autoimmune Hepatitis ... • Drug Induced Hepatitis ... #Causes #Hepatology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
• Legionnaires disease ... • Early acute hepatitis ... • Ischemic hepatitis ... hepatitis (ALT-to-LDH ... 1.5) from viral hepatitis
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
• Infectious: Hepatitis ... NAFLD, Autoimmune hepatitis ... Pregnancy, Alcoholic Hepatitis ... Sepsis, Viral Hepatitis ... #hepatology
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
diagnosis of Alcoholic Hepatitis ... factors • Possible ischemic ... hepatitis (e.g. ... diagnosis #Alcoholic #Hepatitis ... #AH #hepatology