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differential liver causes transaminitis acute dili elevated management abnormal aplastic dehydrogenase druginduced emesis function gastroenterology hematology hepatocellular idiosyncratic induced laboratory
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... > 50x normal - Ischemic ... Patterns #Liver #Injury ... #hepatology #LFTs ... #differential #diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Function Tests (LFTs ... 1000): • DILI (Drug-induced ... liver injury) ... • Ischemic Hepatopathy ... #hepatology #transaminitis
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
- Ichemic hepatitis ... obstruction - Drug-Induced ... liver injury ... #Differential #Hepatology ... #Diagnosis
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
valproate, azoles), Drugs ... • Vascular: Ischemic ... #hepatology #algorithm ... Transaminitis #LFTs ... #hepatitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Algorithm Severe ... /Toxins • Ischemia ... • Alcoholic hepatitis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... Algorithm DILI ... disease, Hepatic ischaemia ... #Diagnosis #Algorithm ... #hepatology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
- Differential Diagnosis ... • Ischemic hepatitis ... inherited, acquired, drug ... rheumatic fever) • Drugs ... #differential #diagnosis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Idiosyncratic Drug-induced ... Chronic - ongoing ↑ LFTs ... gastroenterology #algorithm ... gastroenterology #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
of Acute Liver Injury ... - Differential Diagnosis ... , Recreational Drugs ... Causes #Acute #algorithm ... #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
- Differential Diagnosis ... 15X ULN - Drugs ... , Viral, Ischemia ... Burak @kwburak #LFTs ... #diagnosis #hepatology
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