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diagnosis differential causes hepatitis lfts management transaminitis acidosis alcoholic classification drug druginduced effusion elevation function gastroenterology hepatocellular idiosyncratic induced lactate
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Injury (DILI) ... dose dependent injury ... or symptoms of liver ... gastroenterology #algorithm ... gastroenterology #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Stepwise Diagnosis Algorithm ... involvement, Kidney injury ... disease, Hepatic ischaemia ... #Algorithm #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... (>1000): • DILI ... (Drug-induced liver ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... • Iatrogenic: DILI ... differential #diagnosis #algorithm ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... • Vascular: Ischemic ... #Diagnosis #hepatology ... #algorithm #Transaminitis
Causes of Seizures - Differential Diagnosis Algorithm Unprovoked - Epilepsy: • Focal: Simple, Complex • Generalized: Absence,
Differential Diagnosis Algorithm ... Traumatic brain injury ... Encephalitis, Brain Abscess ... Cerebral Hypoxia, Uremia ... , Liver failure,
Causes of Pleural Effusion - Differential Diagnosis Algorithm Transudate - Hydrostatic • Congestive heart failure • Constrictive
Differential Diagnosis Algorithm ... • Subphrenic abscess ... • Postcardiac injury ... • Asbestos • Uremia ... #Hepatology #causes
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
, - regional ischemia ... or renal injury ... assessment - assess ... 30mmHg) - Severe anemia ... Injury: • Reduced
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Hepatitis - Management Algorithm ... - Acute kidney injury ... HCV, DILI, HCC, ... Hepatitis #Management #Algorithm ... #hepatology
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