11 results
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... , Alcohol-related ... Hepatic ischaemia ... #Liver #Injury ... #hepatology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... Injury Transaminase ... 20x normal - Acute ... Infection (EBV/CMV ... #Injury #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Hepatopathy • Acute ... Viral Hepatitis ... (>1000): • DILI ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... • Iatrogenic: DILI ... ALT Ratios: • Alcoholic ... #injury #hepatitis ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Liver Injury - Differential ... E, B, D, EBV, CMV ... HSV • Toxic: Alcohol ... #Injury #Differential ... #algorithm #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Failure Infections Alcohol-Associated ... Hepatitis (AAH) ... Injury (DILI) ... Failure #Cirrhosis #Hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injuryliver ... Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... #Diagnosis #hepatology ... #algorithm #Transaminitis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
viral hepatitis ... serologies, HCV ... viral hepatitis ... ALT Ratios: • Alcoholic ... #differential #Hepatology
Alcoholic Hepatitis - Management Algorithm
Assess Eligibility for Treatment:
 - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... - Management Algorithm ... kidney injury with ... HCV, DILI, HCC, ... #Algorithm #hepatology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
RBCs, muscle, liver ... : • Early acute ... hepatitisIschemic ... hepatitisAcute ... fever) • Drugs (alcohol