13 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... - Ischemic Hepatitis ... - Acute Viral Hepatitis ... #Patterns #Liver ... #Injury #hepatology
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm

1. Definition: T.bili elevation + >20% conjugated
2. Obtain RUQ
Differential Diagnosis Algorithm ... MRCP, ERCP, liver ... Hyperbilirubinemia #direct #bilirubin ... #gastroenterology ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... function may be abnormal ... differential #diagnosis #algorithm ... #hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
fold elevation, Bilirubin ... fold elevation, Bilirubin ... and hemorrhage Acute ... but variable ++, Bilirubin ... Disease #Pregnancy #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
hepatocellular injury • Bilirubin ... week • Direct bilirubin ... - If both are normal ... Elevation: • Bilirubin ... #differential #Hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Differential Diagnosis Algorithm ... Drugs, Viral, Ischemia ... LFTs #Elevated #Abnormal ... #diagnosis #hepatology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
and unconjugated bilirubin ... and excretion of bilirubin ... —100-fold with acute ... liver failure; ... LiverFailure #Hepatic #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Differential Diagnosis Algorithm ... Drugs/Toxins • Ischemia ... disease US — Normal ... Others #LFTs #Hepatology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
of about 30% of normal ... of hemolysis or liver ... associated with bilirubin ... #hepatology #diagnosis ... #gastroenterology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... disease, Hepatic ischaemia ... dechallenge • Acute ... Injury #Diagnosis #Algorithm ... #hepatology