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diagnosis differential hepatitis injury causes abnormal calling chemistry consultation drug elevation function functiontest giconsult hepatocellular idiosyncratic induced interpretation liverenzymes liverfunctiontests
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... (>1000): • DILI ... injury) • Ischemic ... Differential #Diagnosis #hepatology ... #transaminitis
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
(LFTs) Elevation ... abnormality vs bone Bili ... - Direct (Obstructive ... #Elevation #Transaminitis ... #diagnosis #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... or symptoms of liver ... Diagnosis #Management #gastroenterology ... #algorithm #gastroenterology ... #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Elevated Transaminases ... / Transaminitis ... Trauma: Shock liver ... • Iatrogenic: DILI ... Diagnosis #causes #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Drugs, Viral, Ischemia ... Burak @kwburak #LFTs ... #Elevated #Abnormal ... #hepatology #LiverFunctionTests
The Liver Consult Primer - Guide to calling a consult HPI: - Start with reason for consult
- Vitals - LFTs ... plt, INR, GTT, indirect ... bili/ current MELD ... Calling #Referral #Hepatology ... #Gastroenterology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... specificity to elevated ... life: 1 week • Direct ... #differential #Hepatology ... #transaminitis
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Differential Diagnosis Algorithm ... Drugs/Toxins • Ischemia ... • Others #LFTs ... #Hepatology #LiverEnzymes
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... specificity to elevated ... Half-life: 1 week • Direct ... differential #diagnosis #algorithm ... #hepatology
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