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diagnosis differential causes management lfts transaminitis ascites treatment acute chronic elevated gastroenterology hbv hepatitisb nafld nonalcoholic abnormal aih anemia autoimmune
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... Injury Transaminase ... cirrhosis, Portal ... #Patterns #Liver ... #Injury #hepatology
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
of Severe Acute Liver ... Injury - Ichemic ... injury - Viral ... Wilson disease ... #Differential #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • Cholestatic disease ... hepatitis • Drugs ... Others #LFTs #Hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... HSV • Toxic: Alcohol ... #Injury #Differential ... Causes #Acute #algorithm ... #hepatology
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Non-Malignant • Fatty Liver ... Hemochromatosis • Wilson's Disease ... Inflammatory • Alcoholic ... Primary Biliary Cirrhosis ... #Causes #Hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
• NAFLD • Cirrhosis ... Chronic Viral Hepatitis ... • Acute Viral Hepatitis ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Inflammation - Hepatitis ... 15 percent) - Hepatitis ... Sarcoidosis Toxic - Alcohol ... Nonalcoholic fatty liver ... #Differential #Hepatology
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 Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury → liver ... Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... #Diagnosis #hepatology ... #algorithm #Transaminitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
disease, liver ... Failure Infections Alcohol-Associated ... Hepatitis (AAH) ... Injury (DILI) ... #Hepatology #gastroenterology
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
Hepatitis (AH) ... factors • Possible ischemic ... ) or metabolic liver ... Possible drug-induced liver ... #hepatology #criteria
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