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diagnosis differential causes lfts injury management acute cirrhosis elevated treatment abnormal ah aih albumin ascites autoimmune chemistry criteria dili druginduced
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... 5-10x normal - Chronic ... #Patterns #Liver ... #Injury #hepatology ... #LFTs #transaminitis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Cirrhosis • Chronic ... Viral Hepatitis ... injury) • Ischemic ... Differential #Diagnosis #hepatology ... #transaminitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Failure Infections Alcohol-Associated ... Hepatitis (AAH) ... #Acute #Chronic ... #Cirrhosis #Hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Differential Diagnosis Algorithm ... for Transaminitis ... Drugs, Viral, Ischemia ... #hepatology #LiverFunctionTests
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Transaminases / Transaminitis ... Trauma: Shock liver ... • Autoimmune hepatitis ... See Updated Schema ... Diagnosis #causes #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • NAFLD • Alcohol ... hepatitis • Drugs ... Others #LFTs #Hepatology
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
Hepatitis (AH) ... factors • Possible ischemic ... ) or metabolic liver ... Possible drug-induced liver ... #hepatology #criteria
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... HEV, EBV, CMV), Alcohol-related ... Hepatic ischaemia ... hepatitis fibrosis ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
• Infectious: Hepatitis ... HSV • Toxic: Alcohol ... Medication, Pregnancy, Alcoholic ... Causes #Acute #algorithm ... #hepatology
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